Structure of PDB 6du7 Chain E

Receptor sequence
>6du7E (length=447) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
REYDIIAIGGGSGGIATMNRAGEHGAQAAVIEEKKLGGTCVNVGCVPKKI
MWYGAQIAETFHQFGEDYGFKTTDLNFDFATLRRNRESYIDRARSSYDGS
FKRNGVDLIEGHAEFVDSHTVSVNGELIRAKHIVIATGAHPSIPNIPGAE
LGGSSDDVFAWEELPESVAILGAGYIAVELAGVLHTFGVKTDLFVRRDRP
LRGFDSYIVEGLVKEMERTNLPLHTHKVPVKLEKTTDGITIHFEDGTSHT
ASQVIWATGRRPNVKGLQLEKAGVTLNERGFIQVDEYQNTVVEGIYALGD
VTGEKELTPVAIKAGRTLSERLFNGKTTAKMDYSTIPTVVFSHPAIGTVG
LTEEQAIKEYGQDQIKVYKSSFASMYSACTRNRQESRFKLITAGSEEKVV
GLHGIGYGVDEMIQGFAVAIKMGATKADFDATVAIHPTSSEEFVTMR
3D structure
PDB6du7 The structure and activity of the glutathione reductase from Streptococcus pneumoniae.
ChainE
Resolution2.56 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C41 C46 K49 Y176 E180 H437 E442
Catalytic site (residue number reindexed from 1) C40 C45 K48 Y175 E179 H436 E441
Enzyme Commision number 1.8.1.7: glutathione-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD E G10 G12 S13 G14 E33 E34 K35 G39 T40 C41 G45 C46 K49 H113 A114 T138 G139 Y176 I177 R261 G300 D301 L308 T309 G9 G11 S12 G13 E32 E33 K34 G38 T39 C40 G44 C45 K48 H112 A113 T137 G138 Y175 I176 R260 G299 D300 L307 T308
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004362 glutathione-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0034599 cellular response to oxidative stress
GO:0045454 cell redox homeostasis
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6du7, PDBe:6du7, PDBj:6du7
PDBsum6du7
PubMed30605126
UniProtA0A0U0ARX4

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