Structure of PDB 6dna Chain E

Receptor sequence
>6dnaE (length=393) Species: 9606 (Homo sapiens) [Search protein sequence]
LVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQKIANDNS
LNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGAGALRIG
ADFLARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEK
RGLDLQGFLNDLENAPEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHR
FLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEFFCAQSFSKNFGLYNE
RVGNLTVVGKEPESILQVLSQMEKIVRITWSNPPAQGARIVASTLSNPEL
FEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGMFSFTGL
NPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAV
3D structure
PDB6dna Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
ChainE
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.6.1.1: aspartate transaminase.
2.6.1.3: cysteine transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP E G108 G109 A110 W141 D223 A225 S256 S258 K259 R267 G92 G93 A94 W125 D207 A209 S240 S242 K243 R251
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity
GO:0004609 phosphatidylserine decarboxylase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0047801 L-cysteine transaminase activity
Biological Process
GO:0006094 gluconeogenesis
GO:0006103 2-oxoglutarate metabolic process
GO:0006107 oxaloacetate metabolic process
GO:0006114 glycerol biosynthetic process
GO:0006520 amino acid metabolic process
GO:0006531 aspartate metabolic process
GO:0006532 aspartate biosynthetic process
GO:0006533 aspartate catabolic process
GO:0006536 glutamate metabolic process
GO:0007219 Notch signaling pathway
GO:0008652 amino acid biosynthetic process
GO:0009058 biosynthetic process
GO:0019550 glutamate catabolic process to aspartate
GO:0032869 cellular response to insulin stimulus
GO:0051384 response to glucocorticoid
GO:0055089 fatty acid homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6dna, PDBe:6dna, PDBj:6dna
PDBsum6dna
PubMed30365304
UniProtP17174|AATC_HUMAN Aspartate aminotransferase, cytoplasmic (Gene Name=GOT1)

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