Structure of PDB 6dl7 Chain E

Receptor sequence
>6dl7E (length=180) Species: 9606 (Homo sapiens) [Search protein sequence]
SLIPIVVDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIH
MYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPGM
RHSLPNSRIMIHQPSGGATDIAIQAEEIMKLKKQLYNIYAKHTKQSLQVI
ESAMERDRYMSPMEAQEFGILDKVLVHPPQ
3D structure
PDB6dl7 Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.
ChainE
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.92: endopeptidase Clp.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ONC E E82 H116 Y118 W146 E16 H50 Y52 W80
BS02 ONC E L104 S108 T135 L38 S42 T69
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6dl7, PDBe:6dl7, PDBj:6dl7
PDBsum6dl7
PubMed31056398
UniProtQ16740|CLPP_HUMAN ATP-dependent Clp protease proteolytic subunit, mitochondrial (Gene Name=CLPP)

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