Structure of PDB 6cnk Chain E

Receptor sequence
>6cnkE (length=358) Species: 9606 (Homo sapiens) [Search protein sequence]
DTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQI
MTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGM
YEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSW
TYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITY
DFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLAL
TVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSP
TTHTMAPWVKVVFLEKLPALLFMQQSVSEDWKYVAMVIDRLFLWIFVFVC
VFGTIGMF
3D structure
PDB6cnk Structural principles of distinct assemblies of the human alpha 4 beta 2 nicotinic receptor.
ChainE
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 E F285 C292 I349 F284 C291 I338
BS02 Y01 E S225 R351 W355 S224 R340 W344
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0045211 postsynaptic membrane

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Cellular Component
External links
PDB RCSB:6cnk, PDBe:6cnk, PDBj:6cnk
PDBsum6cnk
PubMed29720657
UniProtP17787|ACHB2_HUMAN Neuronal acetylcholine receptor subunit beta-2 (Gene Name=CHRNB2)

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