Structure of PDB 6c5a Chain E

Receptor sequence

>6c5aE (length=456) Species: 9606 (Homo sapiens) [Search protein sequence]

FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLP
YEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGR
AADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNL
NLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHW
VPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVA
TAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQ
VIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIY
ISKYLMDEGAHLHIYDPKVPREQIVVDLSHDQVSRLVTISDPYEACDGAH
AVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQI
ETIGKK

3D structure

PDB

6c5a The A225L Substitution of hUGDH alters structure and function

Chain

Resolution

2.3 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	T131 E165 K220 N224 C276 D280
Catalytic site (residue number reindexed from 1)	T129 E163 K218 N222 C274 D278
Enzyme Commision number	1.1.1.22: UDP-glucose 6-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAI	E	G11 G13 Y14 V15 D36 V37 R41 V89 N90 T91 T131 E161 E165 C276	G10 G12 Y13 V14 D35 V36 R40 V87 N88 T89 T129 E159 E163 C274
BS02	UPG	E	F162 L163 E165 K220 N224 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442	F160 L161 E163 K218 N222 I229 F263 K265 S267 F270 G271 C274 F275 F336 K337 R433

Gene Ontology

	Molecular Function
GO:0003979	UDP-glucose 6-dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042802	identical protein binding
GO:0051287	NAD binding

	Biological Process
GO:0001702	gastrulation with mouth forming second
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006065	UDP-glucuronate biosynthetic process
GO:0015012	heparan sulfate proteoglycan biosynthetic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0034214	protein hexamerization
GO:0048666	neuron development

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0070062	extracellular exosome

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6c5a, PDBe:6c5a, PDBj:6c5a
PDBsum	6c5a
PubMed
UniProt	O60701\|UGDH_HUMAN UDP-glucose 6-dehydrogenase (Gene Name=UGDH)

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