Structure of PDB 6bo7 Chain E

Receptor sequence
>6bo7E (length=211) Species: 5855 (Plasmodium vivax) [Search protein sequence]
KIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLK
NRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTES
PKHLYVEHYVRVEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKKFEVKT
IAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDLDHLCL
VNDEGIKKFRT
3D structure
PDB6bo7 Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.
ChainE
Resolution2.856 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E144 D145 D148 F197 R210
Catalytic site (residue number reindexed from 1) E127 D128 D131 F180 R193
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG E E144 D145 E127 D128
BS02 MG E S97 T99 E100 S96 T98 E99
BS03 YPG E K77 I146 D148 T149 G150 K151 T152 K176 F197 V198 D204 K76 I129 D131 T132 G133 K134 T135 K159 F180 V181 D187
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:6bo7, PDBe:6bo7, PDBj:6bo7
PDBsum6bo7
PubMed29161011
UniProtA5K7E9

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