Structure of PDB 6aqo Chain E

Receptor sequence
>6aqoE (length=210) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence]
KPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKT
LKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPN
VVDFIRINLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKV
CVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKP
EYAKRYPSKL
3D structure
PDB6aqo Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.
ChainE
Resolution2.64 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E147 D148 D151 Y201 R214
Catalytic site (residue number reindexed from 1) E123 D124 D127 Y177 R190
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 45T E I149 D151 T152 G153 T155 K180 Y201 V202 E208 R214 I125 D127 T128 G129 T131 K156 Y177 V178 E184 R190 PDBbind-CN: -logKd/Ki=6.11,Ki=0.77uM
BS02 MG E E147 D148 E123 D124
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0000310 xanthine phosphoribosyltransferase activity
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0042301 phosphate ion binding
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0020015 glycosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6aqo, PDBe:6aqo, PDBj:6aqo
PDBsum6aqo
PubMed29481567
UniProtQ38CA1

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