Structure of PDB 6am0 Chain E

Receptor sequence
>6am0E (length=257) Species: 284590 (Kluyveromyces lactis NRRL Y-1140) [Search protein sequence]
SLPLLRPFETVSLENAVEDLVVRFILNVPPEDLSTVERVLFHFEEASWFY
TDFVKLMNPYLPNLSIKSFSKIVIDICPLIWNWDITPENALVKFSNYKKT
IPVRGAAIFNDSLSKILLLRGINSKHWSFPRGKIGKDEDDVACCIREVKE
QTGFDLTGFIDADQYVERNMNGKNFKIFLVKGVPEDFEFKPEHKNEIQAI
EWKDFKKLSKAITKNVFLVNSMIRPLSLYVKNEKRAKDENKLKLYAEEHL
KSILGLN
3D structure
PDB6am0 Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis.
ChainE
Resolution2.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E P30 E32 D33 R39 F42 H43 Y98 T101 I102 G136 K137 P29 E31 D32 R38 F41 H42 Y97 T100 I101 G135 K136
BS02 6VQ E W49 D53 K100 H127 R132 K134 K174 F176 E197 F223 W48 D52 K99 H126 R131 K133 K173 F175 E196 F217
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA

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Molecular Function
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Biological Process
External links
PDB RCSB:6am0, PDBe:6am0, PDBj:6am0
PDBsum6am0
PubMed29559651
UniProtQ6CIU1

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