Structure of PDB 6a4b Chain E

Receptor sequence
>6a4bE (length=217) Species: 10090 (Mus musculus) [Search protein sequence]
PRAETFVFLDLEATGLPNMDPEIAEISLFAVHRSSLENPERDDSGSLVLP
RVLDKLTLCMCPERPFTAKASEITGLSSESLMHCGKAGFNGAVVRTLQGF
LSRQEGPICLVAHNGFDYDFPLLCTELQRLGAHLPQDTVCLDTLPALRGL
DRAHSRKSYSLASLFHRYFQAEPSAAHSAEGDVHTLLLIFLHRAPELLAW
ADEQARSWAHIEPMYVP
3D structure
PDB6a4b Structural insights into the duplex DNA processing of TREX2
ChainE
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E E16 A17 L20 K73 I77 H117 N118 D121 Y122 R156 R167 S169 Y170 S171 L172 E12 A13 L16 K69 I73 H113 N114 D117 Y118 R152 R156 S158 Y159 S160 L161
BS02 MG E D14 D123 D10 D119
BS03 MG E D14 E16 D193 D10 E12 D182
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0008296 3'-5'-DNA exonuclease activity
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:6a4b, PDBe:6a4b, PDBj:6a4b
PDBsum6a4b
PubMed30357414
UniProtQ9R1A9|TREX2_MOUSE Three prime repair exonuclease 2 (Gene Name=Trex2)

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