Structure of PDB 5zr1 Chain E

Receptor sequence
>5zr1E (length=460) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
MNVTTPEVAFREYQTNCLASYISADPDITPSNLILQGYSGTGKTYTLKKY
FNANPNLHAVWLEPVELVSWKPLLQAIARTVQYKLKTLYPNIPTTDYDPL
QVEEPFLLVKTLHNIFVQYESLQEKTCLFLILDGFDSLQDLDAALFNKYI
KLNELLPKDSKINIKFIYTMLETSFLQRYSTHCIPTVMFPRYNVDEVSTI
LVMSRCGELMEDSCLRKRIIEEQITDCTDDQFQNVAANFIHLIVQAFHSY
TGNDIFALNDLIDFKWPKYVSRITKENIFEPLALYKSAIKLFLSTDDNLS
QTYDLSIISKYLLIASYICSYLEPRYDASIFSRKTRIIQGRAAYGRRKKK
EVNPRYLQPSLFAIERLLAIFQAIFPIQGKAESGSLSALREESLMKANIE
VFQNLSELHTLKLIATTMNKNIDYLSPKVRWKVNVPWEIIKEISESVHFN
ISDYFSDIHE
3D structure
PDB5zr1 Structure of the origin recognition complex bound to DNA replication origin.
ChainE
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E Q358 R360 Y363 R366 K439 N440 Q339 R341 Y344 R347 K420 N421
BS02 dna E Y345 Y363 G364 R366 T436 M437 Y326 Y344 G345 R347 T417 M418
BS03 AGS E S39 G40 T41 G42 K43 T44 Y45 Y192 I200 I255 F256 S39 G40 T41 G42 K43 T44 Y45 Y192 I200 I255 F256
Gene Ontology
Molecular Function
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006270 DNA replication initiation
GO:0006275 regulation of DNA replication
GO:0030466 silent mating-type cassette heterochromatin formation
Cellular Component
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005664 nuclear origin of replication recognition complex
GO:0031261 DNA replication preinitiation complex
GO:0035361 Cul8-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5zr1, PDBe:5zr1, PDBj:5zr1
PDBsum5zr1
PubMed29973722
UniProtP50874|ORC5_YEAST Origin recognition complex subunit 5 (Gene Name=ORC5)

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