Structure of PDB 5yak Chain E

Receptor sequence
>5yakE (length=219) Species: 9606 (Homo sapiens) [Search protein sequence]
VEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVI
RTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWV
TDLKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIA
CGILLAALQNAGLVTVTTAPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSK
EATVPDLKRKPLDQIMVTV
3D structure
PDB5yak Redox control of iodotyrosine deiodinase
ChainE
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.21.1.1: iodotyrosine deiodinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN E P127 S128 G129 H131 Y212 S216 P57 S58 G59 H61 Y142 S146
BS02 YOF E A130 Y212 A60 Y142 MOAD: Kd=1.5uM
BS03 FMN E R100 R101 S102 R104 L176 T237 T238 A239 R30 R31 S32 R34 L106 T167 T168 A169
BS04 YOF E E157 Y161 L173 K182 E87 Y91 L103 K112 MOAD: Kd=1.5uM
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:5yak, PDBe:5yak, PDBj:5yak
PDBsum5yak
PubMed30052294
UniProtQ6PHW0|IYD1_HUMAN Iodotyrosine deiodinase 1 (Gene Name=IYD)

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