Structure of PDB 5xm1 Chain E

Receptor sequence
>5xm1E (length=98) Species: 10090 (Mus musculus) [Search protein sequence]
PHRYRPGTVALREIRRYQKATELLIRKLPFQRLVREIAQDFKTDLRFQSA
AIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
3D structure
PDB5xm1 Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration.
ChainE
Resolution3.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E H39 R40 Y41 G44 V46 A47 R49 R63 K64 L65 R69 R83 H2 R3 Y4 G7 V9 A10 R12 R26 K27 L28 R32 R46
BS02 dna E H39 R40 Y41 R42 T45 R63 R72 R83 F84 Q85 R116 T118 H2 R3 Y4 R5 T8 R26 R35 R46 F47 Q48 R79 T81
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001556 oocyte maturation
GO:0001649 osteoblast differentiation
GO:0006334 nucleosome assembly
GO:0006997 nucleus organization
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0007338 single fertilization
GO:0007566 embryo implantation
GO:0008283 cell population proliferation
GO:0008584 male gonad development
GO:0030307 positive regulation of cell growth
GO:0031508 pericentric heterochromatin formation
GO:0031509 subtelomeric heterochromatin formation
GO:0035264 multicellular organism growth
GO:0042692 muscle cell differentiation
GO:0048477 oogenesis
GO:0090230 regulation of centromere complex assembly
GO:1902340 negative regulation of chromosome condensation
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000786 nucleosome
GO:0000939 inner kinetochore
GO:0001740 Barr body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xm1, PDBe:5xm1, PDBj:5xm1
PDBsum5xm1
PubMed29643389
UniProtP84244|H33_MOUSE Histone H3.3 (Gene Name=H3-3a)

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