Structure of PDB 5wmh Chain E

Receptor sequence
>5wmhE (length=399) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
SLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEA
GINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQ
SLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLL
DPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVL
SDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAG
PKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRE
RRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSL
ALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPL
3D structure
PDB5wmh Structural basis for substrate recognition and inhibition of prephenate aminotransferase from Arabidopsis.
ChainE
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.6.1.1: aspartate transaminase.
2.6.1.78: aspartate--prephenate aminotransferase.
2.6.1.79: glutamate--prephenate aminotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP E G167 A168 K169 W193 N243 D272 Y275 S305 K306 R314 G97 A98 K99 W123 N173 D202 Y205 S235 K236 R244
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0033853 aspartate-prephenate aminotransferase activity
GO:0033854 glutamate-prephenate aminotransferase activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0008652 amino acid biosynthetic process
GO:0009058 biosynthetic process
GO:0009094 L-phenylalanine biosynthetic process
GO:0009095 aromatic amino acid family biosynthetic process, prephenate pathway
GO:0009793 embryo development ending in seed dormancy
Cellular Component
GO:0005829 cytosol
GO:0009507 chloroplast
GO:0009570 chloroplast stroma

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Molecular Function
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Cellular Component
External links
PDB RCSB:5wmh, PDBe:5wmh, PDBj:5wmh
PDBsum5wmh
PubMed29405514
UniProtQ9SIE1|PAT_ARATH Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase (Gene Name=PAT)

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