Structure of PDB 5vr8 Chain E

Receptor sequence

>5vr8E (length=457) Species: 9606 (Homo sapiens) [Search protein sequence]

FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLP
IYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKG
RAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPN
LNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEH
WVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEV
ATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQ
QVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSI
YISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGA
HAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQ
IETIGKK

3D structure

PDB

5vr8 The entropic force generated by intrinsically disordered segments tunes protein function.

Chain

Resolution

1.999 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	T131 E165 K220 N224 C276 D280
Catalytic site (residue number reindexed from 1)	T130 E164 K219 N223 C275 D279
Enzyme Commision number	1.1.1.22: UDP-glucose 6-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UDX	E	G13 Y14 V15 D36 V37 R41 V89 N90 T91 Y108 S130 T131 K279 R346	G12 Y13 V14 D35 V36 R40 V88 N89 T90 Y107 S129 T130 K278 R345
BS02	UDX	E	F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442	F161 L162 A163 E164 K219 I230 F264 K266 S268 F271 G272 C275 F276 F337 K338 R434

Gene Ontology

	Molecular Function
GO:0003979	UDP-glucose 6-dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042802	identical protein binding
GO:0051287	NAD binding

	Biological Process
GO:0001702	gastrulation with mouth forming second
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006065	UDP-glucuronate biosynthetic process
GO:0015012	heparan sulfate proteoglycan biosynthetic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0034214	protein hexamerization
GO:0048666	neuron development

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0070062	extracellular exosome

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:5vr8, PDBe:5vr8, PDBj:5vr8
PDBsum	5vr8
PubMed	30420606
UniProt	O60701\|UGDH_HUMAN UDP-glucose 6-dehydrogenase (Gene Name=UGDH)

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