Structure of PDB 5umd Chain E

Receptor sequence

>5umdE (length=380) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]

SHRKFERPRHGSLGFLPRKRCKRLRGKIRSFPKDDKEKPPHFTAFMGYKA
GMTHIVREVDKPGSKLHKKEIVEACTIIECAPMVVVGIVGYRETPKGLRI
LSTVWANHVSDEFRRRYYKNWYKSEKKAFTKSLNVPEATKNCLLKRIEKY
CTVLRAICHTQPSKTPLRMKKAHIMEVQINGGSMKEKLEFVKEMLEKNLP
VSTVFNPNEMIDVISVTKGHGTKGVVSRYGVKRLPRKTHRGLRKVACIGA
WHPARVQFQIPRHGQKGYFHRTERNKKIYRIGLKTDKNSASTDADITEKK
ITPMGGFPHYGVVNEDFLLLKGCVAGTKKRPITLRKNIVPQVSRDALAQV
SLKFIDTSSKIGHGRFQTSEEKVKYYGPLK

3D structure

PDB

5umd Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	E	S2 H3 R4 K5 F6 E7 R8 P9 R10 H11 S13 L14 G15 F16 L17 P18 R19 K20 R21 K23 L25 R26 K28 R30 S31 K50 M53 T54 H55 K62 S65 A75 Y92 R93 T95 P96 L99 R100 I101 T104 W106 R116 R117 Y118 Y119 K120 N121 Y123 S125 E126 K128 A129 F130 K132 S133 R156 R169 M170 K171 K172 I175 E177 T218 K219 G220 H221 G222 T223 G225 V227 S228 R229 V232 K233 R234 R237 K238 T239 H240 R241 G242 L243 R244 K245 V246 A247 C248 I249 G250 A251 W252 H253 A255 R256 V257 F259 Q260 R263 H264 Q266 Y269 F270 H271 R272 T273 E274 R275 N276 K277 M305 G306 P309 H310 G312 K322 C324 V325 A326 G327 K329 K330 R331 R336 I339 S360 K361 I362 G363 H364 R366 S370 K373 L380 K381	S1 H2 R3 K4 F5 E6 R7 P8 R9 H10 S12 L13 G14 F15 L16 P17 R18 K19 R20 K22 L24 R25 K27 R29 S30 K49 M52 T53 H54 K61 S64 A74 Y91 R92 T94 P95 L98 R99 I100 T103 W105 R115 R116 Y117 Y118 K119 N120 Y122 S124 E125 K127 A128 F129 K131 S132 R155 R168 M169 K170 K171 I174 E176 T217 K218 G219 H220 G221 T222 G224 V226 S227 R228 V231 K232 R233 R236 K237 T238 H239 R240 G241 L242 R243 K244 V245 A246 C247 I248 G249 A250 W251 H252 A254 R255 V256 F258 Q259 R262 H263 Q265 Y268 F269 H270 R271 T272 E273 R274 N275 K276 M304 G305 P308 H309 G311 K321 C323 V324 A325 G326 K328 K329 R330 R335 I338 S359 K360 I361 G362 H363 R365 S369 K372 L379 K380

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:5umd, PDBe:5umd, PDBj:5umd
PDBsum	5umd
PubMed	28288098
UniProt	Q8IJC6

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