Structure of PDB 5u0c Chain E

Receptor sequence
>5u0cE (length=622) Species: 64320 (Zika virus) [Search protein sequence]
SCAEAPNMKIIGRRIERIRNEHAETWFLDENHPYRTWAYHGSYEAPTQGS
ASSLVNGVVRLLSKPWDVVTGVTGIAMTDTTPYGQQRVFKEKVDTRVPDP
QEGTRQVMNIVSSWLWKELGKRKRPRVCTKEEFINKVRSNAALGAIFEEE
KEWKTAVEAVNDPRFWALVDREREHHLRGECHSCVYNMMGKREKKQGEFG
KAKGSRAIWYMWLGARFLEFEALGFLNEDHWMGRENSGGGVEGLGLQRLG
YILEEMNRAPGGKMYADDTAGWDTRISKFDLENEALITNQMEEGHRTLAL
AVIKYTYQNKVVKVLRPAEGGKTVMDIISRQDQRGSGQVVTYALNTFTNL
VVQLIRNMEAEEVLEMQDLWLLRKPEKVTRWLQSNGWDRLKRMAVSGDDC
VVKPIDDRFAHALRFLNDMGKVRKDTQEWKPSTGWSNWEEVPFCSHHFNK
LYLKDGRSIVVPCRHQDELIGRARVSPGAGWSIRETACLAKSYAQMWQLL
YFHRRDLRLMANAICSAVPVDWVPTGRTTWSIHGKGEWMTTEDMLMVWNR
VWIEENDHMEDKTPVTKWTDIPYLGKREDLWCGSLIGHRPRTTWAENIKD
TVNMVRRIIGDEEKYMDYLSTQ
3D structure
PDB5u0c Structure and function of the Zika virus full-length NS5 protein.
ChainE
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E E439 H443 C448 C451 E172 H176 C181 C184
BS02 ZN E H714 C730 C849 H447 C463 C582
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5u0c, PDBe:5u0c, PDBj:5u0c
PDBsum5u0c
PubMed28345656
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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