Structure of PDB 5tuo Chain E

Receptor sequence
>5tuoE (length=228) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
NTKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQ
FKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLI
NNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFK
EVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIK
KRMKNSPNQRPVQPDYNTVIIKSSAETR
3D structure
PDB5tuo Structure-Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori alpha-Carbonic Anhydrase.
ChainE
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H85 H110 H112 E116 H129 T191
Catalytic site (residue number reindexed from 1) H66 H91 H93 E97 H110 T172
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E H110 H112 H129 H91 H93 H110
BS02 1SA E H110 H129 L190 T191 H91 H110 L171 T172 MOAD: Ki=323nM
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5tuo, PDBe:5tuo, PDBj:5tuo
PDBsum5tuo
PubMed28002963
UniProtA0A0M3KL20

[Back to BioLiP]