Structure of PDB 5tt8 Chain E

Receptor sequence
>5tt8E (length=224) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
KWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKLQFKYA
ASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKT
RPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVAL
DAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMK
NSPNQRPVQPDYNTVIIKSSAETR
3D structure
PDB5tt8 Structure-Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori alpha-Carbonic Anhydrase.
ChainE
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H85 H110 H112 E116 H129 T191
Catalytic site (residue number reindexed from 1) H62 H87 H89 E93 H106 T168
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E H110 H112 H129 H87 H89 H106
BS02 D8W E D107 H110 H112 H129 L190 T191 D84 H87 H89 H106 L167 T168 MOAD: Ki=315nM
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5tt8, PDBe:5tt8, PDBj:5tt8
PDBsum5tt8
PubMed28002963
UniProtA0A0M3KL20

[Back to BioLiP]