Structure of PDB 5s9p Chain E

Receptor sequence
>5s9pE (length=128) Species: 9606 (Homo sapiens) [Search protein sequence]
GHMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAV
KLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYN
KPGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5s9p Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.
ChainE
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YW4 E Q78 F79 Q38 F39 BindingDB: IC50=<50nM
BS02 YW4 E W81 P82 F83 Q85 D88 L92 I146 M149 W41 P42 F43 Q45 D48 L52 I106 M109 BindingDB: IC50=<50nM
External links
PDB RCSB:5s9p, PDBe:5s9p, PDBj:5s9p
PDBsum5s9p
PubMed34543572
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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