Structure of PDB 5oes Chain E

Receptor sequence

>5oesE (length=448) Species: 4113 (Solanum tuberosum)

DPHDIDPKLVQKLANDALVWCSLRGLLVGDRNSERSGTVPGVDMVHAPVA
LIPMSFPESHWKQACEVAPIFNELVDRVSQDGEFLQQSLSRTRKVDPFTS
RLLEIHSKMLEINKIEEIRLGLHRSDYMLDEQTKLLLQIELNTISSSFPG
LSCLVSELHRSLLQQYREDIASDPNRIPANNAVNQFAEALAKAWNEYGDP
RAVIMFAVQAEERNMYDQHWLSASLRERHQVTTIRKTLAEIDALGELQQD
GTLVVDGQAVAVIYFRAGYAPSDYNSESEWKARLLMEQSRAVKCPSISYH
LAGSKKIQQELAKPNVLERFLENKDDIAKLRKCFAGLWSLDESDIVKDAI
DRPELYVMKPQRENNIYGEDVRDALLKLQYILMQRIFPKISHSILMREGI
SHKEQTISELGIYGTYLRNKTEVVINQQAGYLMRTKVSFAVLDSIYLV

3D structure

• PDB: 5oes Effector gene birth in plant parasitic nematodes: Neofunctionalization of a housekeeping glutathione synthetase gene.
• Chain: E
• Resolution: 2.48 Å

Enzymatic activity

• Enzyme Commision number: 6.3.2.3: glutathione synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	E	M141 E153 V370 K372 N381 Y383 M408 R410 I411 E434 K461	M128 E140 V357 K359 N365 Y367 M383 R385 I386 E409 K436
BS02	3GC	E	R137 N155 I157 S158 S160 E225 Q231 R279 Y282	R124 N142 I144 S145 S147 E212 Q218 R266 Y269
BS03	MG	E	L154 G316 E376	L141 G303 E363
BS04	MG	E	D139 E153 E434	D126 E140 E409

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004363 glutathione synthase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0043295 glutathione binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006750 glutathione biosynthetic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5oes, PDBe:5oes, PDBj:5oes
• PDBsum: 5oes
• PubMed: 29641602
• UniProt: M1CSC4