Structure of PDB 5oct Chain E

Receptor sequence
>5octE (length=165) Species: 9606 (Homo sapiens) [Search protein sequence]
YFQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVI
DGETCLLDILDTAGRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRV
KDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVD
DAFYTLVREIRKHKE
3D structure
PDB5oct Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
ChainE
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP E G13 G15 K16 S17 A18 V29 D30 Y32 P34 T35 G60 N116 K117 D119 S145 A146 G17 G19 K20 S21 A22 V33 D34 Y36 P38 T39 G64 N113 K114 D116 S142 A143
BS02 9R5 E K5 S39 D54 L56 T74 G75 K9 S43 D58 L60 T71 G72
BS03 9R5 E H95 Y96 Q99 H92 Y93 Q96
BS04 MG E S17 T35 S21 T39
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5oct, PDBe:5oct, PDBj:5oct
PDBsum5oct
PubMed30093669
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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