Structure of PDB 5oco Chain E

Receptor sequence
>5ocoE (length=173) Species: 9606 (Homo sapiens) [Search protein sequence]
YFQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVI
DGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHY
REQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSA
KTRQGVDDAFYTLVREIRKHKEK
3D structure
PDB5oco Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
ChainE
Resolution1.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP E G13 G15 K16 S17 A18 F28 V29 D30 Y32 P34 T35 G60 N116 K117 D119 L120 S145 A146 G17 G19 K20 S21 A22 F32 V33 D34 Y36 P38 T39 G64 N120 K121 D123 L124 S149 A150
BS02 9RK E E37 Y71 T74 E41 Y75 T78
BS03 MG E S17 T35 S21 T39
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5oco, PDBe:5oco, PDBj:5oco
PDBsum5oco
PubMed30093669
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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