Structure of PDB 5n6i Chain E

Receptor sequence
>5n6iE (length=357) Species: 10090 (Mus musculus) [Search protein sequence]
KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPL
SHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLI
RNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLV
PKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECL
KLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSC
FDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERN
NGFPIFD
3D structure
PDB5n6i cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
ChainE
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E R158 K160 R161 R180 H203 K395 R10 K12 R13 R32 H55 K247
BS02 dna E R161 S165 Y200 K372 R13 S17 Y52 K224
BS03 dna E R244 T334 T338 R96 T186 T190
BS04 dna E K315 R342 K167 R194
BS05 ZN E H378 C384 C385 C392 H230 C236 C237 C244
External links
PDB RCSB:5n6i, PDBe:5n6i, PDBj:5n6i
PDBsum5n6i
PubMed28902841
UniProtQ8C6L5|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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