Structure of PDB 5mwf Chain E

Receptor sequence
>5mwfE (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
MGYFELQLSALRNVNGELLSGACCDGCGHDECDTYVRVCLKEYQAKVTPT
GPCSYGHGATPVLGGNSFYLPPAGQDPGLVVIPFQFAWPRSFTLIVEAWD
WDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDE
NYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCN
LLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWG
GLLCDKDLNG
3D structure
PDB5mwf Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
ChainE
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC E V97 W151 V62 W101
BS02 CA E D51 D65 E66 D68 D25 D30 E31 D33
BS03 CA E D51 D150 W151 D152 D25 D100 W101 D102
BS04 CA E C50 D51 D150 D152 C24 D25 D100 D102
Gene Ontology
Biological Process
GO:0007154 cell communication
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organism development
Cellular Component
GO:0016020 membrane

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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5mwf, PDBe:5mwf, PDBj:5mwf
PDBsum5mwf
PubMed28572448
UniProtQ9Y219|JAG2_HUMAN Protein jagged-2 (Gene Name=JAG2)

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