Structure of PDB 5mnv Chain E

Receptor sequence
>5mnvE (length=390) Species: 1890 (Streptomyces antibioticus) [Search protein sequence]
AVPAYPFSLPHALDLDPHYAELRRDEPVSRVRLPYGEGTAWLVTRMSDAR
IVLGDSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAF
TARRVEEMRPRVRSLVDSLLDDMVAHGSPADLVEFLAVPFPVAVICELLG
VPLEDRDLFRTFSDAMLSSTRAAEIQRVQQDFMVYMDGLVAQRRDAPTED
LLGALALNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTERKRY
ESLVADPALVPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPC
VVHFASANRDEEVFDHADELDFHRERNPHIAFGHGAHHCIGAQLGRLELQ
EALSALVRRFPTLDLAEPVAGLKWKQGMLIRGLERQIVSW
3D structure
PDB5mnv Substrate-induced conformational change in cytochrome P450 OleP.
ChainE
Resolution2.97 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S180 A244 E247 T248 S249 S292 C356 I357 G358 E365 I397
Catalytic site (residue number reindexed from 1) S168 A227 E230 T231 S232 S275 C339 I340 G341 E348 I380
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM E V93 L94 R105 L241 A244 G245 T248 Q252 R298 F321 A348 F349 H354 C356 V81 L82 R93 L224 A227 G228 T231 Q235 R281 F304 A331 F332 H337 C339
BS02 DEB E F84 S295 L396 I397 F72 S278 L379 I380
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5mnv, PDBe:5mnv, PDBj:5mnv
PDBsum5mnv
PubMed30207799
UniProtQ59819

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