Structure of PDB 5mgx Chain E

Receptor sequence
>5mgxE (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
EWLDILGNGLLRKKTLVPGPPGSSRPVKGQVVTVHLQTSLENGTRVQEEP
ELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYGPQGRSPYIPPH
AALCLEVTLKTAVDGPDLEMLTGQERVALANRKRECGNAHYQRADFVLAA
NSYDLAIKAITSSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAA
LRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKT
IHAELSKLVKKHAAQ
3D structure
PDB5mgx The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90.
ChainE
Resolution2.18 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L127 V137 Q138 I153 Y179 L196
Catalytic site (residue number reindexed from 1) L36 V46 Q47 I62 Y88 L105
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E R225 N229 Y232 N277 K284 K307 F310 R311 E336 N339 R134 N138 Y141 N186 K193 K216 F219 R220 E245 N248
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:5mgx, PDBe:5mgx, PDBj:5mgx
PDBsum5mgx
PubMed28278223
UniProtQ14318|FKBP8_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP8 (Gene Name=FKBP8)

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