Structure of PDB 5m45 Chain E

Receptor sequence
>5m45E (length=709) Species: 78245 (Xanthobacter autotrophicus Py2) [Search protein sequence]
RNVQVLGIDAGGTMTDTFFVDQDGDFVVGKAQSTPQNEALGLIASSEDGL
ANWGMSLHEALAQLQTGVYSGTAMLNRVVQRKGLKCGLIVNRGMEDFHRM
GRAVQSHLGYAYEDRIHLNTHRYDPPLVPRHLTRGVVERTDMMGTQVIPL
REDTARDAARDLIAADAEGIVISLLHSYKNPVNERRVRDIVLEEVEKSGK
KIPVFASADYYPVRKETHRTNTTILEGYAAEPSRQTLSKISNAFKERGTK
FDFRVMATHGGTISWKAKELARTIVSGPIGGVIGAKYLGEVLGYKNIACS
DIGGTSFDVALITQGEMTIKNDPDMARLVLSLPLVAMDSVGAGAGSFIRL
DPYTRAIKLGPDSAGYRVGVCWKESGIETVTISDCHMVLGYLNPDNFLGG
AVKLDRQRSVDAIKAQIADPLGLSVEDAAAGVIELLDSDLRDYLRSMISG
KGYSPASFVCFSYGGAGPVHTYGYTEGLGFEDVIVPAWAAGFSAFGCAAA
DFEYRYDKSLDINMPTETPDTDKEKAAATLQAAWEELTKNVLEEFKLNGY
SADQVTLQPGYRMQYRGQLNDLEIESPLAQAHTAADWDQLTDAFNATYGR
VYAASARSPELGYSVTGAIMRGMVPIPKPKIPKEPEEGETPPESAKIGTR
KFYRKKRWVDAQLYHMESLRPGNRVMGPAVIESDATTFVVPDGFETWLDG
HRLFHLREV
3D structure
PDB5m45 Structural Basis for the Mechanism of ATP-Dependent Acetone Carboxylation.
ChainE
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.4.1.6: acetone carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP E G20 T21 M22 G311 G312 A352 F405 L406 G473 A474 D692 A693 T694 T695 G12 T13 M14 G303 G304 A344 F397 L398 G465 A466 D684 A685 T686 T687
BS02 MG E M22 D24 M14 D16
BS03 ACT E R123 K459 R115 K451
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016874 ligase activity
GO:0017168 5-oxoprolinase (ATP-hydrolyzing) activity
GO:0018710 acetone carboxylase activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0140977 cellular detoxification of acetone
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5m45, PDBe:5m45, PDBj:5m45
PDBsum5m45
PubMed28775283
UniProtQ8RM04|ACXA_XANP2 Acetone carboxylase beta subunit (Gene Name=acxA)

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