Structure of PDB 5jer Chain E

Receptor sequence
>5jerE (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
ENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTL
PGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGH
CHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGR
SPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLE
NTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQ
3D structure
PDB5jer Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
ChainE
Resolution2.913 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E R211 V257 Y260 H263 C267 H288 H290 Y292 G349 L362 R23 V69 Y72 H75 C79 H100 H102 Y104 G161 L174
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5jer, PDBe:5jer, PDBj:5jer
PDBsum5jer
PubMed27302953
UniProtQ14653|IRF3_HUMAN Interferon regulatory factor 3 (Gene Name=IRF3)

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