Structure of PDB 5j3h Chain E

Receptor sequence
>5j3hE (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKL
IMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL
GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDECGD
ICNCPATVFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQP
DDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKYVIH
NNKCIPECPSGYTMNSLLCTP
3D structure
PDB5j3h Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.
ChainE
Resolution3.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E R14 Q34 L37 F64 F88 F89 Y91 F96 R118 E120 K121 R10 Q30 L33 F60 F84 F85 Y87 F92 R114 E116 K117
External links
PDB RCSB:5j3h, PDBe:5j3h, PDBj:5j3h
PDBsum5j3h
PubMed27281820
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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