Structure of PDB 5izq Chain E

Receptor sequence
>5izqE (length=206) Species: 9606 (Homo sapiens) [Search protein sequence]
ARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDV
SYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKER
VLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPF
HFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARF
YAAAMS
3D structure
PDB5izq Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
ChainE
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 83A E F62 D81 R106 H135 K136 G137 W140 W171 S174 Y175 F56 D75 R100 H129 K130 G131 W134 W165 S168 Y169 BindingDB: IC50=3.0nM
External links
PDB RCSB:5izq, PDBe:5izq, PDBj:5izq
PDBsum5izq
PubMed27458733
UniProtP15328|FOLR1_HUMAN Folate receptor alpha (Gene Name=FOLR1)

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