Structure of PDB 5iso Chain E

Receptor sequence

>5isoE (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]

SVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWD
SKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSF
KPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFL
KLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVS
ALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGV
LKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVL

3D structure

PDB

5iso STRUCTURE OF FULL LENGTH HUMAN AMPK (NON-PHOSPHORYLATED AT T-LOOP) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991)

Chain

Resolution

2.63 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	AMP	E	T87 T89 D90 V130 I150 H151 R152	T61 T63 D64 V104 I124 H125 R126
BS02	AMP	E	K170 I240 S242 D245 R269 V276 L277 V297 H298 R299	K144 I214 S216 D219 R243 V250 L251 V271 H272 R273
BS03	AMP	E	H151 T200 I204 A205 V225 S226 H298 S314 S316 D317	H125 T174 I178 A179 V199 S200 H272 S288 S290 D291

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004691	cAMP-dependent protein kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008603	cAMP-dependent protein kinase regulator activity
GO:0016208	AMP binding
GO:0019887	protein kinase regulator activity
GO:0019901	protein kinase binding
GO:0043531	ADP binding

	Biological Process
GO:0006110	regulation of glycolytic process
GO:0006468	protein phosphorylation
GO:0006633	fatty acid biosynthetic process
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0010628	positive regulation of gene expression
GO:0031669	cellular response to nutrient levels
GO:0045860	positive regulation of protein kinase activity
GO:0051170	import into nucleus

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0031588	nucleotide-activated protein kinase complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5iso, PDBe:5iso, PDBj:5iso
PDBsum	5iso
PubMed
UniProt	P54619\|AAKG1_HUMAN 5'-AMP-activated protein kinase subunit gamma-1 (Gene Name=PRKAG1)

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