Structure of PDB 5ht0 Chain E

Receptor sequence
>5ht0E (length=261) Species: 77133 (uncultured bacterium) [Search protein sequence]
SRVSTRSSLAEDLRAIGLADGDAVLVHAALRKVGKIVGGPDDILDAMRDV
IGPAGTVLGYADWQLEDEIRDDPAMREHIPAFDPLRSRSIRDNGFWPELI
RTTPGALRSASPGASMAAIGGEAEWFTADHALDYGYGPRSPLGKLVEAKG
KVLMLGAPLDTMTLLHHAEHLADFPNKRILRYEAPILVDGEKVWRWFEEF
DTSDPPDGLADDYFAGIVEEFLATGRGKRGKIGEASSVLVPADEIVAFAV
DWLERWGRTAR
3D structure
PDB5ht0 Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family.
ChainE
Resolution2.752 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.81: aminoglycoside N(3)-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA E H29 A30 A31 R33 P42 Y62 N95 F97 A159 T163 T165 H27 A28 A29 R31 P40 Y60 N93 F95 A157 T161 T163
BS02 COA E Q66 R93 Q64 R91
Gene Ontology
Molecular Function
GO:0008080 N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0046353 aminoglycoside 3-N-acetyltransferase activity
Biological Process
GO:0046677 response to antibiotic

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5ht0, PDBe:5ht0, PDBj:5ht0
PDBsum5ht0
PubMed35338238
UniProtA0A059X981

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