Structure of PDB 5h9e Chain E

Receptor sequence
>5h9eE (length=354) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
SNFINIHVLISHSPSCLNRDDMNMQKDAIFGGKRRVRISSQSLKRAMRKS
GYYAQNIGESSLRTIHLAQLRDVLRQKLGERFDQKIIDKTLALLSGKSVD
EAEKISADAVTPWVVGEIAWFCEQVAKAEADNLDDKKLLKVLKEDIAAIR
VNLQQGVDIALSGRMATSGMMTELGKVDGAMSIAHAITTHQVDSDIDWFT
AVDDLQEQGSAHLGTQEFSSGVFYRYANINLAQLQENLGGASREQALEIA
THVVHMLATEVPGAKQRTYAAFNPADMVMVNFSDMPLSMANAFEKAVKAK
DGFLQPSIQAFNQYWDRVANGYGLNGAAAQFSLTAQVKQMPTLEQLKSWV
RNNG
3D structure
PDB5h9e Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli.
ChainE
Resolution3.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna E R20 D21 D22 K27 S40 Q42 S43 K45 R46 R49 M166 F200 T201 A202 V203 A265 K266 R19 D20 D21 K26 S39 Q41 S42 K44 R45 R48 M165 F199 T200 A201 V202 A264 K265
BS02 dna E D109 A110 M166 T168 G210 S211 H213 L214 D108 A109 M165 T167 G209 S210 H212 L213
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0051607 defense response to virus
GO:0099048 CRISPR-cas system
Cellular Component
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5h9e, PDBe:5h9e, PDBj:5h9e
PDBsum5h9e
PubMed26863189
UniProtQ46899|CASC_ECOLI CRISPR system Cascade subunit CasC (Gene Name=casC)

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