Structure of PDB 5grb Chain E

Receptor sequence
>5grbE (length=208) Species: 12059 (Enterovirus) [Search protein sequence]
KHRIEPVCLIIRGSPGTGKSLATGIIARAIADKYHSSVYSLPPDPDHFDG
YKQQVVTVMDDLCQNPDGKDMSLFCQMVSTVDFIPPMASLAEAGVSFTSK
FVIASTNATNIISDSDAIRRRFYMDCDIEVTDSYKTDLGRLDAGRAAKLC
SENNTANFKRCSPLVCGKAIQLRDRKSKVRYSVDTVVSELIREYSNRSAI
GNTIEALF
3D structure
PDB5grb Crystal structure of 2C helicase from enterovirus 71
ChainE
Resolution2.803 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS E P131 G132 G134 K135 S136 L137 D177 P15 G16 G18 K19 S20 L21 D61
BS02 ZN E C270 C286 C150 C166
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:5grb, PDBe:5grb, PDBj:5grb
PDBsum5grb
PubMed
UniProtB9VUU3|POLG_HE71 Genome polyprotein

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