Structure of PDB 5fpv Chain E

Receptor sequence
>5fpvE (length=341) Species: 9606 (Homo sapiens) [Search protein sequence]
LNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRA
SYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYC
TPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTIL
DLVEEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPE
HGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEA
GEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVK
ISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLK
3D structure
PDB5fpv Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
ChainE
Resolution2.44 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G171 Y178 H189 E191 H277 S289
Catalytic site (residue number reindexed from 1) G156 Y163 H174 E176 H262 S274
Enzyme Commision number 1.14.11.66: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69: [histone H3]-trimethyl-L-lysine(36) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN E H189 E191 H277 H174 E176 H262
BS02 MMK E Y133 Y178 F186 H189 E191 K207 W209 H277 T290 N291 Y125 Y163 F171 H174 E176 K192 W194 H262 T275 N276
BS03 ZN E C235 H241 C307 C309 C220 H226 C292 C294
External links
PDB RCSB:5fpv, PDBe:5fpv, PDBj:5fpv
PDBsum5fpv
PubMed27214403
UniProtO75164|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)

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