Structure of PDB 5eel Chain E

Receptor sequence
>5eelE (length=102) Species: 9606 (Homo sapiens) [Search protein sequence]
QLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVK
HYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCT
RV
3D structure
PDB5eel Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
ChainE
Resolution2.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E H433 I436 E440 R529 V530 H5 I8 E12 R101 V102
BS02 peptide E R438 R462 K478 H479 Y480 L481 M495 R10 R34 K50 H51 Y52 L53 M67
External links
PDB RCSB:5eel, PDBe:5eel, PDBj:5eel
PDBsum5eel
PubMed27257138
UniProtQ14451|GRB7_HUMAN Growth factor receptor-bound protein 7 (Gene Name=GRB7)

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