Structure of PDB 5ed4 Chain E

Receptor sequence
>5ed4E (length=224) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
TPEARVLVVDDEANIVELLSVSLKFQGFEVYTATNGAQALDRARETRPDA
VILDVMMPGMDGFGVLRRLRADGIDAPALFLTARDSLQDKIAGLTLGGDD
YVTKPFSLEEVVARLRVILRRAGRNVRLTFADIELDEETHEVWKAGQPVS
LSPTEFTLLRYFVINAGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRR
KIDTGEKRLLHTLRGVGYVLREPR
3D structure
PDB5ed4 Structural basis of DNA sequence recognition by the response regulator PhoP in Mycobacterium tuberculosis.
ChainE
Resolution2.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.3.1: alkaline phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E S175 T177 W203 N212 Y217 Y220 S152 T154 W180 N189 Y194 Y197
BS02 dna E K195 N212 E215 S216 S219 T235 R237 G238 Y241 K172 N189 E192 S193 S196 T212 R214 G215 Y218
BS03 CA E D28 D71 M73 D11 D54 M56
Gene Ontology
Molecular Function
GO:0000156 phosphorelay response regulator activity
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000160 phosphorelay signal transduction system
GO:0006355 regulation of DNA-templated transcription
GO:0006979 response to oxidative stress
GO:0009247 glycolipid biosynthetic process
GO:0010628 positive regulation of gene expression
GO:0044315 protein secretion by the type VII secretion system
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
GO:0046889 positive regulation of lipid biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0032993 protein-DNA complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5ed4, PDBe:5ed4, PDBj:5ed4
PDBsum5ed4
PubMed27079268
UniProtP71814

[Back to BioLiP]