Structure of PDB 5e24 Chain E

Receptor sequence
>5e24E (length=424) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
HIEEKKLTRDAMEKYMRERNDMVIVILHAKVAQKSYGNEKRFFCPPPCIY
LFGSGWTRRYEEMLQQGEGEQGAQLCAFIGIGSSDQDMQQLDLNGKQYCA
AKTLFISDSDKRKHFMLSVKMFYGNGHDIGVFNSKRIKVISKPSKKKQSL
KNADLCIASGTNVALFNRLRSQTVSTRYLHVEGGHFHASSTQWGAFTIHL
LDDNESESEEFQVRDGYIHYGATVKLVCSVTGMALPRLIIRKVDKQMALL
EADDPVSQLHKCAFYMKDTDRMYLCLSQEKIIQFQATPCPKEPNKEMIND
GACWTIISTDKAEYQFYEGMGPVASPVTPVPIVNSLNLNGGGDVAMLELS
GDNFTPHLQVWFGDVEAETMYRCTETLLCVVPEISQFRGEWLWVRQPTQV
PISLVRNDGIIYATGLTFTYTPEP
3D structure
PDB5e24 Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster.
ChainE
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E K132 Y134 K244 R268 S269 Q270 K34 Y36 K146 R170 S171 Q172
BS02 dna E K138 R139 F140 K240 K243 R266 R268 K359 K40 R41 F42 K142 K145 R168 R170 K261
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:5e24, PDBe:5e24, PDBj:5e24
PDBsum5e24
PubMed27404588
UniProtP28159|SUH_DROME Suppressor of hairless protein (Gene Name=Su(H))

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