Structure of PDB 5cfb Chain E

Receptor sequence
>5cfbE (length=339) Species: 9606 (Homo sapiens) [Search protein sequence]
SPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDY
RVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANF
HEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLES
FGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFT
CIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGIT
TVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVS
RAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKI
3D structure
PDB5cfb Crystal structure of human glycine receptor-alpha 3 bound to antagonist strychnine.
ChainE
Resolution3.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SY9 E F63 R65 L117 F55 R57 L109
BS02 SY9 E F159 Y202 T204 F207 F151 Y194 T196 F199
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0016594 glycine binding
GO:0022824 transmitter-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5cfb, PDBe:5cfb, PDBj:5cfb
PDBsum5cfb
PubMed26416729
UniProtO75311|GLRA3_HUMAN Glycine receptor subunit alpha-3 (Gene Name=GLRA3)

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