Structure of PDB 5ccv Chain E

Receptor sequence
>5ccvE (length=852) Species: 408870 (Dengue virus 3 Philippines/H87/1956) [Search protein sequence]
ETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGEITHHAVS
RGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKVTEVRGYTKG
GPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSPSPTV
EESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVR
NPLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTHRRPTIEKDVD
LGAGTRHVNAEPETPNMDVIGERIKRIKEEHSSTWHYDDENPYKTWAYHG
SYEVKATGSASSMINGVVKLLTKPWDVVPMVTQMAMTDTTPFGQQRVFKE
KVDTRTPRPMPGTRKVMEITAEWLWRTLGRNKRPRLCTREEFTKKVRTNA
AMGAVFTEENQWDSARAAVEDEEFWKLVDRERELHKLGKCGSCVYNMMIW
YMWLGARYLEFEALGFLNEDHWFSRENSYSGVEGEGLHKLGYILRDISKI
PGGAMYADDTAGWDTRITEDDLHNEEKITQQMDPEHRQLANAIFKLTYQN
KVVKVQRPTPKGTVMDIISRKDQRGSGQVGTYGLNTFTNMEAQLIRQMEG
EGVLSKADLENPHPLEKKITQWLETKGVERLKRMAISGDDCVVKPIDDRF
ANALLALNDMGKVRKDIPQWQPSKGWHDWQQVPFCSHHFHELIMKDGRKL
VVPCRPQDELIGRARISQGAGWSLRETACLGKAYAQMWALMYFHRRDLRL
ASNAICSAVPVHWVPTSRTTHQWMTTEDMLTVWNRVWIEDNPWMEDKTPV
TTWEDVPYLGKREDQWCGSLIGLTSRATWAQNILTAIQQVRSLIGNEEFL
DY
3D structure
PDB5ccv Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface.
ChainE
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E E437 H441 C446 E431 H435 C440
BS02 ZN E H712 H714 C728 H688 H690 C704
BS03 SAH E G81 G86 W87 K105 H110 D131 V132 F133 D146 G75 G80 W81 K99 H104 D125 V126 F127 D140
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5ccv, PDBe:5ccv, PDBj:5ccv
PDBsum5ccv
PubMed26895240
UniProtP27915|POLG_DEN3P Genome polyprotein

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