Structure of PDB 5cbz Chain E

Receptor sequence
>5cbzE (length=76) Species: 32644 (unidentified) [Search protein sequence]
PPSKVCLVCGDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCII
DKIRRKNCPACRLRKCLQAGMNLGAR
3D structure
PDB5cbz Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
ChainE
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E C431 H432 Y433 K442 K446 C16 H17 Y18 K27 K31 PDBbind-CN: Kd=0.106uM
BS02 dna E S440 R447 Y455 R470 K471 R477 S25 R32 Y40 R55 K56 R62 PDBbind-CN: Kd=0.106uM
BS03 ZN E C421 C424 C438 C441 C6 C9 C23 C26
BS04 ZN E C457 C463 C473 C476 C42 C48 C58 C61
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5cbz, PDBe:5cbz, PDBj:5cbz
PDBsum5cbz
PubMed26715749
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

[Back to BioLiP]