Structure of PDB 5b4w Chain E

Receptor sequence
>5b4wE (length=478) Species: 9606 (Homo sapiens) [Search protein sequence]
TAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLD
SRDCLPPVMPDECPQAQPTNNPNQLLLVSPGALVVCGSVHQGVCEQRRLG
QLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSR
GGIPPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASA
YFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEGGRYGLIQA
AAVATSREVAHGEVLFAAFSSAGASALCAFPLDEVDRLANRTRDACYTRE
GRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEA
TPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYST
QSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVASCAQHLDCASCLAH
RDPYCGWCVLLGRCSRRSECSQWLWSFQ
3D structure
PDB5b4w Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide
ChainE
Resolution2.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E V292 F294 T395 P396 I397 E399 D414 G415 H416 T417 L433 G434 P435 S437 V264 F266 T351 P352 I353 E355 D370 G371 H372 T373 L389 G390 P391 S393
BS02 peptide E S241 R245 G270 R272 E352 P391 S213 R217 G242 R244 E308 P347
Gene Ontology
Molecular Function
GO:0017154 semaphorin receptor activity
Biological Process
GO:0071526 semaphorin-plexin signaling pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5b4w, PDBe:5b4w, PDBj:5b4w
PDBsum5b4w
PubMed27984026
UniProtO43157|PLXB1_HUMAN Plexin-B1 (Gene Name=PLXNB1)

[Back to BioLiP]