Structure of PDB 5akc Chain E

Receptor sequence
>5akcE (length=663) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
RQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPADRETMAAELQRTNPAE
LLYAEDFAEMSLIEGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFGV
ENAPRGLSAAGALLQYAKCTQRTTLPHIRSITMEREQDSIIMDAATRRNL
EITQNLAGGAENTLASVLDSTVTPMGSRMLKRWLHMPVRDTRVLLERQQT
IGALQDFTAGLQPVLRQVGDLERILARLALRTARPRDLARMRHAFQQLPE
LRAQLETVDSAPVQALREKMGEFAELRDLLERAIIDTPPVLVRDGGVIAS
GYNEELDEWRALADGATDYLERLEVRERERTGLDTLKVGFNAVHGYYIQI
SRGQSHLAPINYMRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQL
YEELFDLLLPHLEALQQSASALAELDVLVNLAERAYTLNYTSPTFIDKPG
IRITEGRHPVVEQVLNEPFIANPLNLSPQRRMLIITGPNMGGKSTYMRQT
ALIALMAYIGSYVPAQKVEIGPIDRIFTRVGAFMVEMTETANILHNATEY
SLVLMDEIGRGTSTYDGLSLAWAVAENLANKIKALTLFATHYFELTQLPE
KMEGVANVHLDALEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIK
RARQKLRELESIS
3D structure
PDB5akc MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.
ChainE
Resolution6.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP E F596 I597 N616 M617 G619 K620 S621 T622 H760 F469 I470 N489 M490 G492 K493 S494 T495 H623
BS02 ANP E F670 M671 F533 M534
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008301 DNA binding, bending
GO:0016887 ATP hydrolysis activity
GO:0030983 mismatched DNA binding
GO:0032136 adenine/cytosine mispair binding
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0000018 regulation of DNA recombination
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006974 DNA damage response
Cellular Component
GO:0005829 cytosol
GO:0032300 mismatch repair complex
GO:1990710 MutS complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5akc, PDBe:5akc, PDBj:5akc
PDBsum5akc
PubMed26163658
UniProtP23909|MUTS_ECOLI DNA mismatch repair protein MutS (Gene Name=mutS)

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