Structure of PDB 4zk4 Chain E

Receptor sequence
>4zk4E (length=211) Species: 6500,9606 [Search protein sequence]
YKDDDDKLHSQANLMRLKSDLFNRYPGPTKDDPLTVTLGFTLQDIVKADS
STNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSS
TRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFG
SWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQYKHDIKYNCCEEIY
PDVVLVVKFRE
3D structure
PDB4zk4 Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with 7-(5-isopropoxy-pyridin-3-yl)-1-methyl-1,7-diaza-spiro[4.4]nonane.
ChainE
Resolution1.901 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TII E Y93 W147 V148 C190 C191 Y195 Y98 W152 V153 C195 C196 Y200
BS02 MG E D-3 H1 D5 H9
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zk4, PDBe:4zk4, PDBj:4zk4
PDBsum4zk4
PubMed
UniProtP32297|ACHA3_HUMAN Neuronal acetylcholine receptor subunit alpha-3 (Gene Name=CHRNA3);
Q8WSF8

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