Structure of PDB 4zda Chain E

Receptor sequence
>4zdaE (length=735) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
PTIIYTLTDEAPLLATYAFLPVVRKFAEAAGIDVKTSDISVAARILAEFG
DHLTEEQRVPDNLGELGALTQDPSANIIKLPNISASVPQLLAAIKELQGK
GYNVPDYPANPKTDDEKKIKDRYAKILGSAVNPVLREGNSDRRAPKAVKE
YARKHPHSMGEWSQASRTHVATMKTGDFYHGEKSMTLDRDRRVKMVLKTK
SGEEIVLKPEVKLDAGDIIDSMYMSKKALIAFYEEQIEDAYKTGVMFSLH
VKATMMKVSHPIVFGHAVKVFYKDAFAKHEKLFDELGVNVNNGLSDLYDK
IEALPASQREEIIEDLHKCHEHRPELAMVDSAKGISNFHSPSDVIVDASM
PAMIRLGGKMYGADGRTKDTKAVNPESTFSRMYQEMINFCKTHGQFDPTT
MGTVPNVGLMAQKAEEYGSHDKTFEIPEDGVADIVDIDTGEVLLTQNVEE
GDIWRMPIVKDAPIRDWVKLAVTRARLSGMPVVFWLDTERPHEVELRKKV
KEYLKDHDTEGLKIQIMPQVWAMRYTLERVVRGKDTIAATGNILRDYLTD
LFPILELGTSAKMLSIVPLMAGGGLYETGAGGSAPKHVHQLVEENHLRWD
SLGEFLALGASLEDMGNKTGNEKAKVLAKALDTATGKLLEENKSPSRRTG
ELDNRGSQFYLSLFWAQALAEQTEDAELAERFKPLAKALAEQEEAIVSEL
NSVQGKTVDIGGYYYPDPEKTSEVMRPSKTFNTTL
3D structure
PDB4zda crystal structure of isocitrate dehydrogenase in complex with isocitrate and Mn from M. smegmatis
ChainE
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN E D352 D551 D555 D347 D546 D550
Gene Ontology
Molecular Function
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:4zda, PDBe:4zda, PDBj:4zda
PDBsum4zda
PubMed
UniProtA0QSZ3

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