Structure of PDB 4z9m Chain E

Receptor sequence
>4z9mE (length=369) Species: 9606 (Homo sapiens) [Search protein sequence]
LFPPSADYPDLRKHNNCMAECLTPAIYAKLRNKVTPNGYTLDQCIQTGVD
NPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVMKHTTDLD
ASKITQGQFDEHYVLSSRVRTGRSIRGLSLPPACTRAERREVENVAITAL
EGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWP
DARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVER
LIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKDPRFSKIL
ENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVD
CEKKLERGQDIKVPPPLPQ
3D structure
PDB4z9m Crystal structure of human sarcomeric mitochondrial creatine kinase
ChainE
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R166 E266 R270 C317 S319 R326 R354 V359
Catalytic site (residue number reindexed from 1) R120 E220 R224 C271 S273 R280 R308 V313
Enzyme Commision number 2.7.3.2: creatine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E S162 R164 R166 H225 M274 R326 V329 H330 R354 G357 G358 V359 D369 S116 R118 R120 H179 M228 R280 V283 H284 R308 G311 G312 V313 D323
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004111 creatine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006936 muscle contraction
GO:0016310 phosphorylation
GO:0046314 phosphocreatine biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4z9m, PDBe:4z9m, PDBj:4z9m
PDBsum4z9m
PubMed
UniProtP17540|KCRS_HUMAN Creatine kinase S-type, mitochondrial (Gene Name=CKMT2)

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