Structure of PDB 4yig Chain E

Receptor sequence
>4yigE (length=220) Species: 10249 (Vaccinia virus Copenhagen) [Search protein sequence]
DPMNSVTVSHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDK
FFIQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISR
LTGVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHI
TKHVSVLYCLGKTDFSNIRAKLESPVTTIVGYHPAARDRQFEKDRSFEII
NVLLELDNKVPINWAQGFIY
3D structure
PDB4yig Crystal Structure of the Vaccinia Virus Uracil-DNA Glycosylase in Complex with DNA.
ChainE
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E D68 P69 Y70 P71 K87 S88 G159 K160 T161 Y180 H181 R185 D70 P71 Y72 P73 K89 S90 G161 K162 T163 Y182 H183 R187
BS02 dna E R185 R187 R187 R189
BS03 URA E D68 Y70 F79 N120 H181 D70 Y72 F81 N122 H183
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004844 uracil DNA N-glycosylase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0006281 DNA repair
GO:0039693 viral DNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4yig, PDBe:4yig, PDBj:4yig
PDBsum4yig
PubMed26045555
UniProtP20536|UNG_VACCC Uracil-DNA glycosylase (Gene Name=OPG116)

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