Structure of PDB 4yga Chain E

Receptor sequence
>4ygaE (length=442) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
AIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKE
SLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRK
RFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRII
DFGLSTHFEASKKKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGC
PPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRI
SARDALDHEWIQTYTKPSLDNAILNIRQFQQKLAQAALLYMGSKLTSQDE
TKELTAIFHKMDKNGDGQLDRAELIEGYKELMRMKGSMLDASAVEHEVDQ
VLDAVDFDKNGYIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKIS
STELATIFGVSDTWKSVLSEVDKNNDGEVDFDEFQQMLLKLC
3D structure
PDB4yga Allosteric activation of apicomplexan calcium-dependent protein kinases.
ChainE
Resolution2.94 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D174 K176 E178 N179 D195 T214
Catalytic site (residue number reindexed from 1) D130 K132 E134 N135 D151 T167
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA E D368 N370 D372 Q374 E379 D312 N314 D316 Q318 E323
BS02 CA E D415 D417 N419 Y421 E426 D356 D358 N360 Y362 E367
BS03 CA E D451 D453 S455 K457 E462 D392 D394 S396 K398 E403
BS04 CA E D485 N487 D489 E491 D493 E496 D422 N424 D426 E428 D430 E433
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calcium/calmodulin-dependent protein kinase activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0009931 calcium-dependent protein serine/threonine kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4yga, PDBe:4yga, PDBj:4yga
PDBsum4yga
PubMed26305940
UniProtQ9BJF5

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