Structure of PDB 4xst Chain E

Receptor sequence
>4xstE (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKL
IMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL
GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDECG
DICPNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL
GNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLH
HKHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCP
3D structure
PDB4xst Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors.
ChainE
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E N15 L36 F64 F88 F89 V94 F96 R118 E120 N11 L32 F60 F84 F85 V90 F92 R114 E116
External links
PDB RCSB:4xst, PDBe:4xst, PDBj:4xst
PDBsum4xst
PubMed26027733
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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