Structure of PDB 4xk9 Chain E

Receptor sequence
>4xk9E (length=212) Species: 6500 (Aplysia californica) [Search protein sequence]
DDKLHSQANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKADSS
TNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSST
RPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGS
WVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYI
DVNLVVKFRERR
3D structure
PDB4xk9 Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal alpha 7 from Muscle alpha 12 beta gamma delta nAChRs.
ChainE
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 41J E T36 Y55 I118 T40 Y59 I122 PDBbind-CN: -logKd/Ki=9.07,Kd=0.86nM
BS02 41J E Y93 W147 V148 Y188 C191 Y195 Y97 W151 V152 Y192 C195 Y199 PDBbind-CN: -logKd/Ki=9.07,Kd=0.86nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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External links
PDB RCSB:4xk9, PDBe:4xk9, PDBj:4xk9
PDBsum4xk9
PubMed26004441
UniProtQ8WSF8

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